Intracellular tracking of drug release from pH-sensitive polymeric nanoparticles via FRET for synergistic chemo-photodynamic therapy
نویسندگان
چکیده
منابع مشابه
A facile strategy to generate polymeric nanoparticles for synergistic chemo-photodynamic therapy.
Synergistic therapy is a promising strategy for cancer treatment. A nanoparticle with chemo-photodynamic properties was fabricated via π-π stacking interactions between the drug and photosensitizer. It exhibited efficient anticancer activity both in vitro and in vivo.
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Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis or phagocytosis. Such drug molecules are thus confined in endolysosomes, where reduced pH and degradative enzymes may destroy them without therapeutic gain. Efficient escape of...
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ژورنال
عنوان ژورنال: Journal of Nanobiotechnology
سال: 2019
ISSN: 1477-3155
DOI: 10.1186/s12951-019-0547-2